Anti-Cosmo and his fellow Anti-Fairies are released when Timmy foolishly wishes them out. Anti-Cosmo and his wife introduce themselves to Timmy before dubbing him as the hero that released them. Timmy luckily draws out all the Anti-Fairies with lots of bad luck and tricks them into going through the door that leads back to Fairy World. Jorgen then proceeds to lock the Anti-Fairies back up into their imprisonment.
Due to Cosmo's fagiggly gland going bad, he will need a transplant in order to continue his job as godparent. This is the direct opposite of Anti-Cosmo whose fagiggly gland is going good. Since Jorgen hates both Cosmo and Anti-Cosmo, he refuses to let Anti-Cosmo out of prison. After a couple of attempts, the trio are able to get Anti-Cosmo out in order for Cosmo to get his transplant. It works, but Anti-Cosmo escapes, but we then find out part of Cosmo and Anti-Cosmo's personalities had been transplanted to each other during the transplant.